The TP53 Codon 72 Arginine Polymorphism Is Found with Increased TP53 Somatic Mutations in HPV(−) and in an Increased Percentage among HPV(+) Norwegian HNSCC Patients

Background: Somatic TP53 mutations are frequent in head and neck squamous cell carcinoma (HNSCC) important pathogenic factors. Objective: To study relative to the presence of human papillomavirus (HPV) tumors HNSCC patients. Methods: Using a custom-made next-generation sequencing (NGS) panel on formalin-fixed, paraffin-embedded tumor tissue, we analyzed somatic single-nucleotide polymorphism (SNP) codon 72 (P72R; rs1042522) (proline → arginine) from 104 patients with HNSCC. Results: Only 2 44 HPV-positive (HPV(+)) had mutation, as opposed 42/60 HPV-negative (HPV(−)) (p < 0.001). Forty-five different were detected. Furthermore, HPV(−) patients, determined an 80% prevalence R72 cohort versus 40% P72 = A higher percentage oral cavity SCC than oropharyngeal (OP) 0.012). 39/44 HPV(+) harbored contrast group 0.024). Conclusions: Our observations show that is associated being HPV(+). We also report